Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study

作者：Wei Wu, Yali Zheng, Liping Tian, Jianbo Lai, Chanchan Hu, Peng Zhang, Jingkai Chen, Jianbo Hu, Manli Huang, Ning Wei, Weijuan Xu, Weihua Zhou, Shaojia Lu, Jing Lü, Hongli Qi, Dandan Wang, Xiaoyi Zhou, Jinfeng Duan, Yi Xu, Shaohua Hu · 发表于：Scientific Reports · 年份：2017 · DOI：10.1038/srep40530 · 被引用次数：61 · 研究领域：Tryptophan and brain disorders、Bipolar Disorder and Treatment、Stress Responses and Cortisol

This study aimed to investigate the less known activation pattern of T lymphocyte populations and immune checkpoint inhibitors on immunocytes in patients with bipolar II disorder depression (BD) or major depression (MD). A total of 23 patients with BD, 22 patients with MD, and 20 healthy controls (HCs) were recruited. The blood cell count of T lymphocyte subsets and the plasma level of cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were selectively investigated. The expression of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), programmed cell death protein 1 (PD-1) and its ligands, PD-L1 and PD-L2, on T lymphocytes and monocytes, was detected. In results, blood proportion of cytotoxic T cells significantly decreased in BD patients than in either MD patients or HCs. The plasma level of IL-6 increased in patients with BD and MD. The expression of TIM-3 on cytotoxic T cells significantly increased, whereas the expression of PD-L2 on monocytes significantly decreased in patients with BD than in HCs. These findings extended our knowledge of the immune dysfunction in patients with affective disorders.