ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

作者：Zhaomin Li, Peng Zhang, Aimin Yan, Zhengyu Guo, Yuguang Ban, Jin Li, Chen Shi, Hui Yang, Yongzheng He, Jianping Li, Ying Guo, Wen Zhang, Ehsan Hajiramezanali, Huangda An, Darlene Fajardo, J. William Harbour, Yijun Ruan, Stephen D. Nimer, Peng Yu, Xi Chen, Mingjiang Xu, Feng‐Chun Yang · 发表于：Science Advances · 年份：2017 · DOI：10.1126/sciadv.1601602 · 被引用次数：44 · 研究领域：Acute Myeloid Leukemia Research、Genomics and Chromatin Dynamics、RNA Research and Splicing

reduces the genome binding of RAD21 and SMC1A and alters the expression of ASXL1/cohesin target genes in LK cells. Our study underscores the ASXL1-cohesin interaction as a novel means to maintain normal sister chromatid separation and regulate gene expression in hematopoietic cells.