Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo

作者：You Lv, Ye Tao, Huipeng Wang, Jiaying Zhao, Wenjie Chen, Xin Wang, Chenxia Shen, Yibin Wu, Yuankun Cai · 发表于：World Journal of Gastroenterology · 年份：2017 · DOI：10.3748/wjg.v23.i4.603 · 被引用次数：24 · 研究领域：Molecular Biology Techniques and Applications、Bacterial Identification and Susceptibility Testing、Diphtheria, Corynebacterium, and Tetanus

AIM: enterotoxin-2 (BFT-2, or Fragilysin) on colorectal tumorigenesis in mice induced by azoxymethane/dextran sulfate sodium (AOM/DSS). METHODS: = 20, 20 μg) group. Mice weight, tumor formation and pathology were analyzed. Immunohistochemistry determined Ki-67 and Caspase-3 expression in normal and tumor tissues of colorectal mucosa. RESULTS: < 0.05). CONCLUSION: Oral administration with lower-dose biologically active recombinant BFT-2 inhibited colorectal tumorigenesis in mice.