HnRNP-L mediates bladder cancer progression by inhibiting apoptotic signaling and enhancing MAPK signaling pathways

作者：Daojun Lv, Huayan Wu, Rongwei Xing, Fangpeng Shu, Bin Lei, Chengyong Lei, Xumin Zhou, Bo Wan, Yang Yu, Liren Zhong, Xiangming Mao, Ya-guang Zou · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.14600 · 被引用次数：42 · 研究领域：RNA Research and Splicing、RNA modifications and cancer、Molecular Biology Techniques and Applications

// Daojun Lv 1, * , Huayan Wu 1, * , Rongwei Xing 4, * , Fangpeng Shu 1 , Bin Lei 1 , Chengyong Lei 1 , Xumin Zhou 1 , Bo Wan 1 , Yu Yang 2 , Liren Zhong 1 , Xiangming Mao 1, 2 , Yaguang Zou 3 1 Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P. R. China 2 Department of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong Province, 518036, China 3 Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P. R. China 4 Department of Urology, Affiliated Weihai Second Municipal Hospital of Qingdao University, Weihai 264200, P. R. China * These authors contributed equally to this work Correspondence to: Xiangming Mao, email: mxming2014@163.com Yaguang Zou, email: 18620050609@163.com Keywords: bladder cancer, heterogeneous nuclear ribonucleoprotein L, epithelial-mesenchymal transition, intrinsic apoptosis, MAPK Received: August 05, 2016      Accepted: January 03, 2017      Published: January 11, 2017 ABSTRACT Heterogeneous nuclear ribonucleoprotein L (hnRNP-L) is a promoter of various kinds of cancers, but its actions in bladder cancer (BC) are unclear. In this study, we investigated the function and the underlying mechanism of hnRNP-L in bladder carcinogenesis. Our results demonstrated that enhanced hnRNP-L expression in BC tissues was associated with poor overall survival of BC patients. Depletion of hnRNP-L s...