Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer

作者：Yunyun Li, Zhongzu Zhang, Zhenghua Xiao, Ying Lin, Tangshu Luo, Qin Zhou, Xiaojing Zhang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.14738 · 被引用次数：33 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases、Reproductive System and Pregnancy

// Yunyun Li 1, * , Zhongzu Zhang 2, * , Zhenghua Xiao 1 , Ying Lin 1 , Tangshu Luo 1 , Qin Zhou 3 , Xiaojing Zhang 1 1 Department of Gynecology and Obstetrics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, PR China 2 Department of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, PR China 3 Department of Gynecology and Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China * These authors contributes to this work Correspondence to: Qin Zhou, email: zhouqin_doctor@126.com Xiaojing Zhang, email: zhangxj_gyn@163.com Keywords: cervical cancer, miR-29b, STAT3, chemotherapy, EMT Received: November 14, 2016      Accepted: January 11, 2017      Published: January 19, 2017 ABSTRACT Radiotherapy combined with platinum-based chemotherapy is the standard-of-care of locally advanced cervical cancer (CC) patients, while nearly 50% of patients do not respond to standard chemotherapy. Thus, identification of relative molecules participated in chemotherapy might provide new insights in the treatment of CC. In this study, we found a cohort of miRNAs were dysregulated upon treatment with cisplatin, among of which miR-29b was the most upregulated one. We further detected its expression in CC tissues, and found that miR-29b was significantly suppressed in CC and its precancerous lesions, HSIL tissues, and was negatively related with tum...