SPECT and PET radiopharmaceuticals for molecular imaging of apoptosis: from bench to clinic

作者：Xiaobo Wang, Feng Han, Shichao Zhao, Junling Xu, Xinyu Wu, Jing Cui, Ying Zhang, Yuhua Qin, Zhiguo Liu, Gao Tang, Yongju Gao, Wenbin Zeng · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.14730 · 被引用次数：43 · 研究领域：Cell death mechanisms and regulation、Radiopharmaceutical Chemistry and Applications、RNA Interference and Gene Delivery

// Xiaobo Wang 1,2 , Han Feng 3 , Shichao Zhao 4 , Junling Xu 1 , Xinyu Wu 1 , Jing Cui 1 , Ying Zhang 1 , Yuhua Qin 3 , Zhiguo Liu 2,5 , Tang Gao 2 , Yongju Gao 1 and Wenbin Zeng 2 1 Department of Nuclear Medicine, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Zhengzhou, China 2 Xiangya School of Pharmaceutical Sciences and Molecular Imaging Research Center, Central South University, Changsha, China 3 Department of Pharmacy, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Zhengzhou, China 4 Department of Cardiology, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Zhengzhou, China 5 Department of Nuclear Medicine, Shandong Cancer Hospital and Institute, Shandong University, Jinan, China Correspondence to: Wenbin Zeng, email: // Yongju Gao, email: // Keywords : SPECT, PET, radiopharmaceuticals, apoptosis, clinical status Received : November 02, 2016 Accepted : January 09, 2017 Published : January 18, 2017 Abstract Owing to the central role of apoptosis in many human diseases and the wide-spread application of apoptosis-based therapeutics, molecular imaging of apoptosis in clinical practice is of great interest for clinicians, and holds great promises. Based on the well-defined biochemical changes for apoptosis, a rich assortment of probes and approaches have been developed for molecular imaging of apoptosis with various imaging modalities....