First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease

作者：Jenny Dörnemann, Chiara Burzio, Axelle Ronsse, Armand Sprecher, Hilde De Clerck, Michel Van Herp, Marie-Claire Kolié, Vesselina Yosifiva, Séverine Caluwaerts, Anita K. McElroy, Annick Antierens · 发表于：The Journal of Infectious Diseases · 年份：2016 · DOI：10.1093/infdis/jiw493 · 被引用次数：130 · 研究领域：Viral Infections and Outbreaks Research、Disaster Response and Management、Viral Infections and Vectors

A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.