Aminoacyl-tRNA-Utilizing Enzymes in Natural Product Biosynthesis

作者：Mireille Moutiez, Pascal Belin, Muriel Gondry · 发表于：Chemical Reviews · 年份：2017 · DOI：10.1021/acs.chemrev.6b00523 · 被引用次数：117 · 研究领域：RNA and protein synthesis mechanisms、Peptidase Inhibition and Analysis、Biochemical and Molecular Research

Aminoacyl-tRNAs were long thought to be involved solely in ribosome-dependent protein synthesis and essential primary metabolism processes, such as targeted protein degradation and peptidoglycan synthesis. About 10 years ago, an aminoacyl-tRNA-dependent enzyme involved in the biosynthesis of the antibiotic valanimycin was discovered in a Streptomyces strain. Far from being an isolated case, this discovery has been followed by the description of an increasing number of aminoacyl-tRNA-dependent enzymes involved in secondary metabolism. This review describes the three groups of aminoacyl-tRNA-dependent enzymes involved in the synthesis of natural products. Each group is characterized by a particular chemical reaction, and its members are predicted to share a specific fold. The three groups are cyclodipeptide synthases involved in diketopiperazine synthesis, LanB-like dehydratases involved in the posttranslational modification of ribosomal peptides, and transferases from various biosynthesis pathways.