Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis

作者：Franziska Faber, Parameth Thiennimitr, Luisella Spiga, Mariana X. Byndloss, Yael Litvak, Sara D. Lawhon, Helene Andrews‐Polymenis, Sebastian Winter, Andreas J. Bäumler · 发表于：PLoS Pathogens · 年份：2017 · DOI：10.1371/journal.ppat.1006129 · 被引用次数：196 · 研究领域：Gut microbiota and health、Salmonella and Campylobacter epidemiology、Escherichia coli research studies

Intestinal inflammation caused by Salmonella enterica serovar Typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. Here we show that one of the carbon sources driving this respiratory expansion in the mouse model is 1,2-propanediol, a microbial fermentation product. 1,2-propanediol utilization required intestinal inflammation induced by virulence factors of the pathogen. S. Typhimurium used both aerobic and anaerobic respiration to consume 1,2-propanediol and expand in the murine large intestine. 1,2-propanediol-utilization did not confer a benefit in germ-free mice, but the pdu genes conferred a fitness advantage upon S. Typhimurium in mice mono-associated with Bacteroides fragilis or Bacteroides thetaiotaomicron. Collectively, our data suggest that intestinal inflammation enables S. Typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product.