A successful pregnancy by intracytoplasmic sperm injection using ejaculate sperm from an infertile man with 46, XX/46, XY true hermaphrodite

作者：Ping Li, Yan-Wei Sha, Yan-Kun Sha, Lu Ding, Shao-Bin Lin, Zhiyong Ji, Xu Wang, Yueqiang Song · 发表于：Asian Journal of Andrology · 年份：2017 · DOI：10.4103/1008-682x.190329 · 被引用次数：15 · 研究领域：Sexual Differentiation and Disorders、Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities、Sperm and Testicular Function

Dear Editor, True hermaphroditism is a condition in which the gonads, genital morphology, and sexuality simultaneously show both male and female characteristics (ovaries and testes) or in which both types of gonadal tissue exist in a single gonad (known as an ovariotestis). True hermaphroditism associated with a chimeric or 46, XX/46, XY karyotype is extremely rare, and the genitalia of those affected can be characterized as female, male, or mixed.123 The cause of true hermaphroditism has not been determined because the condition is relatively rare and has a diverse phenotype.4 The majority of masculine individuals experience varying degrees of low fertility or sterility because the chimeric karyotype prevents complete development of the male and female gonads, though there are some exceptions.5 Dysfunctional spermatogenesis usually is characterized by severe oligospermia, asthenospermia, or azoospermia. Some masculine individuals experience dyszoospermia, leading to varying degrees of low fertility or sterility,6 which is typically not observed in feminine patients with true hermaphroditism,78 Assisted reproductive technology (ART) is an ideal alternative for true hermaphrodites.9 In 2005, Sugawara et al. reported a case of successful delivery by a woman impregnated through intracytoplasmic sperm injection (ICSI) using frozen-thawed sperm obtained by testicular biopsy from an infertile 46, XX/46, XY true hermaphrodite.10 Here, we report a successful pregnancy obtained by ICS...