Computer‐aided design and synthesis of CdTe@SiO 2 core–shell molecularly imprinted polymers as a fluorescent sensor for the selective determination of sulfamethoxazole in milk and lake water

作者：Wanzhen Xu, Yingchun Wang, Weihong Huang, Yu Luan, Yanfei Yang, Hong Liu, Wenming Yang · 发表于：Journal of Separation Science · 年份：2016 · DOI：10.1002/jssc.201601180 · 被引用次数：26 · 研究领域：Analytical chemistry methods development、Pharmaceutical and Antibiotic Environmental Impacts、Advanced biosensing and bioanalysis techniques

In this work, a molecular dynamics simulation method was introduced to compute the preassembled system of molecular imprinted polymers for sulfamethoxazole monomer. The results revealed that the ratio of sulfamethoxazole as template molecule to 3‐aminopropyltriethoxysilane as functional monomer to tetraethylorthosilicate as cross‐linker of 10:10:40 led to the most stable template‐functional monomer cluster. Based on the result of computational simulation, CdTe@SiO 2 core–shell imprinted polymers, a cadmium telluride quantum dots layer on the surface of aminofunctionalized SiO 2 , were synthesized as the fluorescent sensor. Then, a series of measures were used to characterize the structure and morphology to get optimal sensors. The concentration range was 5.0–30.0 μmol/L between molecular imprinted polymers at CdTe at SiO 2 , and sulfamethoxazole of the fluorescence intensity. To further verify the reliability and accuracy of the fluorescent sensor, the application was successfully by analyzing sulfamethoxazole in pure milk and lake water. The results showed the recoveries were above 96.89% with a relative standard deviation of 1.25–5.45%, and the fluorescence sensor with selective recognition provides an alternative solution for the determination of sulfamethoxazole.