Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling

作者：Jing Li, Andrew Volk, Jun Zhang, Joseph Cannova, Shaojun Dai, Caiqin Hao, Cheng-Long Hu, Jiewen Sun, Yan Xu, Wei Wei, Peter Breslin, Sucha Nand, Jianjun Chen, Ameet R. Kini, Jiang Zhu, Jiwang Zhang · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.14220 · 被引用次数：36 · 研究领域：NF-κB Signaling Pathways、Cytokine Signaling Pathways and Interactions、Immune cells in cancer

// Jing Li 1, * , Andrew Volk 2, * , Jun Zhang 1 , Joseph Cannova 2 , Shaojun Dai 1 , Caiqin Hao 1 , Chenglong Hu 1 , Jiewen Sun 1 , Yan Xu 1 , Wei Wei 2 , Peter Breslin 2, 3, 4 , Sucha Nand 2 , Jianjun Chen 5 , Ameet Kini 2, 6 , Jiang Zhu 7 , Jiwang Zhang 2, 6 1 Department of Biology, College of Life and Environment Science, Shanghai Normal University, Shanghai, 200234, People’s Republic of China 2 Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA 3 Department of Biology, Loyola University Chicago, Chicago, IL 60660, USA 4 Department of Molecular and Cellular Physiology, Loyola University Medical Center, Maywood, IL 60153, USA 5 Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA 6 Department of Pathology, Loyola University Medical Center, Maywood, IL. 60153, USA 7 State Key Laboratory for Medical Genomics and Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, People’s Republic of China * These authors have contributed equally to this work Correspondence to: Jiwang Zhang: email: jzhang@lumc.edu Keywords: leukemia stem cell, NF-kappa B, IL-1, TNF, JNK Received: September 22, 2016     Accepted: November 23, 2016     Published: December 26, 2016 ABSTRACT We previously reported that autocrine TNF-α (TNF) is res...