Testin is a tumor suppressor in non-small cell lung cancer

作者：Ming Wang, Qian Wang, Wenjia Peng, Junfeng Hu, Zuyi Wang, Hao Liu, Linian Huang · 发表于：Oncology Reports · 年份：2016 · DOI：10.3892/or.2016.5316 · 被引用次数：13 · 研究领域：Lung Cancer Treatments and Mutations、Chromatin Remodeling and Cancer、Testicular diseases and treatments

The Testin gene was previously identified in the fragile chromosomal region FRA7G at 7q31.2. It has been implicated in several types of cancers including prostate, ovarian, breast and gastric cancer. In the present study, we investigated the function of the candidate tumor-suppressor Testin gene in non-small cell lung cancer (NSCLC). In NSCLC cell lines, we observed lower expression of Testin compared to that noted in normal human bronchial epithelial cells. MTT assays, flow cytometry, clonogenic assay and invasion assay showed that the overexpression of the Testin gene inhibited cancer cell proliferation, invasion and colony formation. In tumor xenograft models, Testin markedly inhibited lung cancer cell xenograft formation and growth in athymic nude mice. Taken together, these data suggest that Testin plays an important role in the development and progression of NSCLC. Testin may be an effective novel target in NSCLC prevention and treatment.