Elevated plasma interleukin-37 playing an important role in acute coronary syndrome through suppression of ROCK activation

作者：Tengyu Yang, Fang Fang, Ya–Wen Chen, Jing Ma, Xiao Zhaowen, Songfeng Zou, Na Zheng, Dewen Yan, Songyan Liao, Shaoyuan Chen, Hongchen Fang, Chekmen Yu, Jie Liu, Ming Dong · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.14195 · 被引用次数：25 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Chemokine receptors and signaling、Psoriasis: Treatment and Pathogenesis

// Tengyu Yang 1, * , Fang Fang 2, * , Yawen Chen 1 , Jing Ma 1 , Zhaowen Xiao 1 , Songfeng Zou 1 , Na Zheng 1 , Dewen Yan 4 , Songyan Liao 1 , Shaoyuan Chen 3 , Hongchen Fang 3 , Chekmen Yu 2 , Jie Liu 1 , Ming Dong 1 1 Division of Pathophysiology, Medical College, Shenzhen University, Shenzhen, Guangdong, China 2 Division of cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Li Ka Shing Institute of Health and Sciences, Institute of Vascular Medicine, The Chinese University of Hong Kong, Hong Kong, China 3 Cardiology Division, Department of Medicine, The Nanshan Hostipal, Shenzhen, Guangdong, China 4 Department of Endocrinology, The First Affiliated Hospital of Shenzhen University, Shenzhen, China * These authors have contributed equally to this work Correspondence to: Ming Dong, email: dongm@szu.edu.cn Keywords: interleukin -37, acute coronary syndrome, ROCK activity Received: October 15, 2016     Accepted: November 24, 2016     Published: December 25, 2016 ABSTRACT Objective : The plasma level of interleukin-37 is elevated in patients with acute coronary syndrome, however, its function during the onset and progress of the disease remains unclear. This study aimed to investigate the clinical significance of IL-37 in acute coronary syndrome and its underlying mechanism. Methods : 124 patients with acute coronary syndrome and 40 healthy controls were recruited in this study. Plasma interleukin-37 levels were...