Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance

作者：Jun Xue, Xueliang Wu, Xiantao Huang, Ming Qu, Fei Guo, Guangyuan Sun, Pengcheng Zhang, Lei Han, Liming Pan · 发表于：Asian Pacific Journal of Tropical Medicine · 年份：2016 · DOI：10.1016/j.apjtm.2016.11.010 · 被引用次数：9 · 研究领域：Cancer, Lipids, and Metabolism、Angiogenesis and VEGF in Cancer、Cancer-related molecular mechanisms research

OBJECTIVE: To study the expression of RUNX3 in colorectal adenocarcinoma tissues and its correlation with microvessel density (MVD), and investigate the clinical pathological prognostic significance of RUNX3 and MVD in patients with colorectal cancer. METHODS: The expression value of RUNX3 and MVD in 70 specimens' colorectal adenocarcinoma tissues were detected by immunohistochemistry staining technique. The correlation between their expression and the clinicopathologic features was also investigated. RESULTS: The expression value of RUNX3 and the positive rates of RUNX3 in colorectal adenocarcinoma tissues were 3.25 ± 1.14 and 25.71% (18/70). The expression value of MVD in colorectal adenocarcinoma tissues was 13.14 ± 3.23. Expression of RUNX3 and MVD value were correlated with CEA, serosal invasion, liver metastasis, lymph node metastasis, and TNM stage (P < 0.01). The expression value of RUNX3 had negative correlations with that of MVD. CONCLUSIONS: The high expression of RUNX3 could inhibit tumor microvascular generation in order to have negative control response on invasion and distant metastasis.