MiR-433-3p suppresses cell growth and enhances chemosensitivity by targeting CREB in human glioma

作者：Shupeng Sun, Xiuyu Wang, Xinnv Xu, Hui Di, Jixiang Du, Bin Xu, Qiong Wang, Jinhuan Wang · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.13789 · 被引用次数：79 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases、Cancer-related molecular mechanisms research

// Shupeng Sun 1, * , Xiuyu Wang 1, 2, * , Xinnv Xu 3, * , Hui Di 4 , Jixiang Du 2 , Bin Xu 2 , Qiong Wang 1 , Jinhuan Wang 1 1 Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300350, China 2 The Graduate School, Tianjin Medical University, Tianjin 300070, China 3 Key Laboratory for Critical Care Medicine of the Ministry of Health, Tianjin First Center Hospital, Tianjin 300192, China 4 Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 071000, China * These authors have contributed equally to this work Correspondence to: Qiong Wang, email: lailwq@126.com Jinhuan Wang, email: wangjinhuanfch@126.com Keywords: miR-433-3p, CREB, glioma, carcinogenesis, chemosensitivity Received: June 16, 2016     Accepted: November 22, 2016     Published: December 03, 2016 ABSTRACT Previous studies reported that miR-433 exerts function widely in human tumorigenesis and development. Here, we further investigate the potential role of miR-433 in glioma. Quantitative real-time PCR demonstrated that miR-433-3p and miR-433-5p were low expressed in glioma tissues and cell lines. Functional studies suggested that the overexpression of miR-433-3p suppressed proliferation, induced apoptosis and inhibited invasion and migration of human glioma cells. But the growth and metastasis of glioma cells were not significantly infl...