The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

作者：Jacqueline A. L. MacArthur, Emily Bowler-Barnett, María Cerezo, Laurent Gil, Peggy Hall, Emma Hastings, Heather Junkins, Aoife McMahon, Annalisa Milano, Joannella Morales, Zoë May Pendlington, Danielle Welter, Tony Burdett, Lucia A. Hindorff, Paul Flicek, Fiona Cunningham, Helen Parkinson · 发表于：Nucleic Acids Research · 年份：2016 · DOI：10.1093/nar/gkw1133 · 被引用次数：2407 · 研究领域：Genetic Associations and Epidemiology、Bioinformatics and Genomic Networks、Gene expression and cancer classification

The NHGRI-EBI GWAS Catalog has provided data from published genome-wide association studies since 2008. In 2015, the database was redesigned and relocated to EMBL-EBI. The new infrastructure includes a new graphical user interface (www.ebi.ac.uk/gwas/), ontology supported search functionality and an improved curation interface. These developments have improved the data release frequency by increasing automation of curation and providing scaling improvements. The range of available Catalog data has also been extended with structured ancestry and recruitment information added for all studies. The infrastructure improvements also support scaling for larger arrays, exome and sequencing studies, allowing the Catalog to adapt to the needs of evolving study design, genotyping technologies and user needs in the future.