Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer

作者：Lei Ma, Yongjian Zhou, Xiaojun Luo, Hai Feng Gao, Xubin Deng, Yingjie Jiang · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.13670 · 被引用次数：115 · 研究领域：Cancer-related molecular mechanisms research、Circular RNAs in diseases、MicroRNA in disease regulation

// Lei Ma 1, 6, * , Yongjian Zhou 2, * , Xiaojun Luo 3 , Hai Gao 4, 5 , Xubin Deng 1 , Yingjie Jiang 2, * 1 Cancer Hospital of Guangzhou Medical University, Guangzhou, China 2 Department of Gastroenterology, the First Hospital of Guangzhou, Guangzhou, China 3 Cancer Center, TCM-Integrated Hospital, Southern Medical University, Guangzhou, China 4 Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China 5 Xiamen Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen, China 6 Department of Gastroenterology, Guangzhou Medical University, Guangzhou, China * These authors contributed equally to this work Correspondence to: Lei ma, email: leima_01@yeah.net Xiaojun Luo, email: carl@smu.edu.cn Hai Gao, email: hai_gao@126.com Xubin Deng, email: xubindeng@126.com Keywords: lncRNA XIST, miR-497, MACC1, gastric cancer Received: April 20, 2016 Accepted: October 19, 2016 Published: November 28, 2016 ABSTRACT Abnormal expression of long non-coding RNA (lncRNAs) often contributes to unrestricted growth and invasion of cancer cells. LncRNA XIST expression is up-regulated in several cancers, however, its modulatory mechanism in gastric cancer (GC) has not been elucidated. In the present study, we found that XIST expression was significantly increased in GC tissues and cell lines. LncRNA XIST promoted cell cycle progression from the G1 phase to the S phase and protected cells from apoptosis, which contributed to GC cell growth. LncRNA XIST also contributed to GC c...