Synergistic effects of polydatin and vitamin C in inhibiting cardiotoxicity induced by doxorubicin in rats

作者：Huilin Wang, Xiaohua Cui, Hai‐Lun Yu, Rong Wu, Xu Xu, Jianping Gao · 发表于：Fundamental and Clinical Pharmacology · 年份：2016 · DOI：10.1111/fcp.12258 · 被引用次数：16 · 研究领域：Vitamin C and Antioxidants Research、Chemotherapy-induced cardiotoxicity and mitigation、Coenzyme Q10 studies and effects

Abstract The purpose of this study was to assess the synergistic effect of polydatin and vitamin C on attenuating cardiotoxicity induced by doxorubicin ( DOX ) in rats. Polydatin could significantly increase the activity of superoxide dismutase ( SOD ) and the heart rate, attenuate myocardial pathological damage, decrease malondialdehyde ( MDA ) content, slightly increase arterial pressure and glutathione peroxidase ( GSH ‐Px) activity, reduce intervals of QRS , QT , and ST , and lower free fatty acid ( FFA ) content. The combination of polydatin and vitamin C could significantly increase arterial pressure and heart rate, decrease QRS interval and slightly reduce ST and QT intervals, significantly attenuate myocardial pathological damage, increase the activities of GSH ‐Px,T‐ SOD , Na + K + ‐ ATP ase, and Ca 2+ Mg 2+ ‐ ATP ase, elevate phosphocreatine ( PC r) and adenosine triphosphate ( ATP ) contents, slightly increase adenosine diphosphate ( ADP ) and total adenine nucleotide ( TAN ) contents and PC r/ ATP , and significantly decrease the contents of MDA and FFA , when compared with those in the DOX group. Meanwhile, the improvement effects on FFA content, the activities of ATP ase and SOD , and contents of ATP and TAN in combination group were more obvious than those in polydatin group, and the improvement effects on arterial pressure, heart rate, interval of QRS , GSH ‐Px activity, and MDA , ADP , and PC r contents in combination group were slightly obvious when compared...