Palladium-Catalyzed Arylation of Ketones and Acetonitrile withOrthoAlkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes

作者：Chuanhu Lei, Jia‐Jia Cao, Jianrong Steve Zhou · 发表于：Organic Letters · 年份：2016 · DOI：10.1021/acs.orglett.6b03130 · 被引用次数：28 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Catalytic Alkyne Reactions

Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes.