The Minasarc study: A case-control study measuring mineral exposome in sarcoidosis

作者：Vincent Michel, Catherine Cavalin, Catinon Mikael, C. Chemarin, Rio Stephane, Élisabeth Roux, P Mathieu, Blanchet Anne-Sophie, Vuillermoz Blas Sylvie, Natalizio Audrey, Pison Christophe, Arbib François, Bonneterre Vincent, Valeyre Dominique, Freynet Olivia, Mornex Jean-Francois, Freymond Nathalie, Pacheco Yves, Thivolet Francoise, Kambouchner Marianne, B. Jean-Francois, Rosental Paul-andré · 年份：2016 · DOI：10.1183/13993003.congress-2016.pa397 · 被引用次数：191 · 研究领域：Sarcoidosis and Beryllium Toxicity Research

Introduction: it has been suggested that sarcoidosis could be associated with exposure to inorganic particles (Newman LS Curr Opin All Clin Immunol 2012; 12:145-50, Vincent M et al Am J Ind Med 2015; 58:S31-8). Objectives: in order to test this hypothesis the Minasarc study was designed to evaluate the mineral exposome by a specific questionnaire (SQ) and a mineralogical analysis performed on BALs by optical and electron microscopy in patients and healthy volunteers (HV). We present here the results obtained by the SQ which can be considered as a tool for global assessment of the “whole life” exposure to inorganic particles in occupational and environmental contexts. Methods: The study was performed on 20 patients with sarcoidosis and 20 HV. Every HV was matched to a patient by sex, age and smoking habit. The SQ was calibrated with a representative sample of the French population (n=825) in the ELIPSSilice survey (ANR-10-Eqpx-19-01) and the result was expressed as a “dust score”. Scores were compared by a Wilcoxon signed-rank test. Results: The “dust score” was found significantly higher in patients with sarcoidosis than in HV (p=0,036; Wilcoxon signed-rank test). Moreover we found a significant overrepresentation of people exposed to building activities among the cases. However this remains to be assessed on a larger series. Conclusion: The SQ demonstrated a significantly higher level of exposure to inorganic dusts in patients with sarcoidosis compared to HV. Such preliminar...