The origin of fibrogenic myofibroblasts in fibrotic liver

作者：Tatiana Kisseleva · 发表于：Hepatology · 年份：2016 · DOI：10.1002/hep.28948 · 被引用次数：227 · 研究领域：Liver physiology and pathology、Liver Disease Diagnosis and Treatment、Organ Transplantation Techniques and Outcomes

Liver fibrosis results from chronic liver injury of different etiologies. It is characterized by dysregulation of physiological remodeling, activation of myofibroblasts, and formation of a fibrous scar. Myofibroblasts develop contractile functions and secrete the extracellular matrix proteins that form this fibrous scar. Myofibroblasts are not present in the normal liver but activate and proliferate in response to injury and inflammation. This review summarizes the understanding and controversies on the contribution of cell populations to the myofibroblasts in liver fibrosis. (Hepatology 2017;65:1039-1043).