The Neurospora Transcription Factor ADV-1 Transduces Light Signals and Temporal Information to Control Rhythmic Expression of Genes Involved in Cell Fusion

作者：Rigzin Dekhang, Cheng Wu, Kristina Smith, Teresa M. Lamb, Matthew Peterson, Erin Bredeweg, Oneida Ibarra, Jillian M. Emerson, Nirmala Karunarathna, Anna Lyubetskaya, Elham Azizi, Jennifer Hurley, Jay Dunlap, James E. Galagan, Michael Freitag, Matthew S. Sachs, Deborah Bell‐Pedersen · 发表于：G3 Genes Genomes Genetics · 年份：2017 · DOI：10.1534/g3.116.034298 · 被引用次数：36 · 研究领域：Light effects on plants、Circadian rhythm and melatonin、Photosynthetic Processes and Mechanisms

Light and the circadian clock have a profound effect on the biology of organisms through the regulation of large sets of genes. Toward understanding how light and the circadian clock regulate gene expression, we used genome-wide approaches to identify the direct and indirect targets of the light-responsive and clock-controlled transcription factor ADV-1 in Neurospora crassa A large proportion of ADV-1 targets were found to be light- and/or clock-controlled, and enriched for genes involved in development, metabolism, cell growth, and cell fusion. We show that ADV-1 is necessary for transducing light and/or temporal information to its immediate downstream targets, including controlling rhythms in genes critical to somatic cell fusion. However, while ADV-1 targets are altered in predictable ways in Δadv-1 cells in response to light, this is not always the case for rhythmic target gene expression. These data suggest that a complex regulatory network downstream of ADV-1 functions to generate distinct temporal dynamics of target gene expression relative to the central clock mechanism.