Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport

作者：Roger Sidney Goody, Matthias Philipp Müller, Yao‐Wen Wu · 发表于：Biological Chemistry · 年份：2016 · DOI：10.1515/hsz-2016-0274 · 被引用次数：92 · 研究领域：Cellular transport and secretion、Lipid Membrane Structure and Behavior、Hemoglobin structure and function

Our understanding of the manner in which Rab proteins regulate intracellular vesicular transport has progressed remarkably in the last one or two decades by application of a wide spectrum of biochemical, biophysical and cell biological methods, augmented by the methods of chemical biology. Important additional insights have arisen from examination of the manner in which certain bacteria can manipulate vesicular transport mechanisms. The progress in these areas is summarized here.