Toxicity assessment of nanoparticles in various systems and organs

作者：Yuan Yang, Zhen Qin, Wei Liang Zeng, Ting Yang, Yubin Cao, Chaorong Mei, Kuang Yu · 发表于：Nanotechnology Reviews · 年份：2016 · DOI：10.1515/ntrev-2016-0047 · 被引用次数：214 · 研究领域：Nanoparticles: synthesis and applications、Heavy Metal Exposure and Toxicity

Abstract In the past decades, much attention has been paid to toxicity assessment of nanoparticles prior to clinical and biological applications. Whilein vitrostudies have been increasing constantly,in vivostudies of nanoparticles have not established a unified system until now. Predictive models and validated standard methods are imperative. This review summarizes the current progress in approaches assessing nanotoxicity in main systems, including the hepatic and renal, gastrointestinal, pulmonary, cardiovascular, nervous, and immune systems. Histopathological studies and specific functional examinations in each system are elucidated. Related injury mechanisms are also discussed.