Altered Brain Activity in Unipolar Depression Revisited

作者：Veronika Müller, Edna C. Cieslik, Ilinca Serbanescu, Angela R. Laird, Peter T. Fox, Simon B. Eickhoff · 发表于：JAMA Psychiatry · 年份：2016 · DOI：10.1001/jamapsychiatry.2016.2783 · 被引用次数：328 · 研究领域：Bipolar Disorder and Treatment、Treatment of Major Depression、Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

IMPORTANCE: During the past 20 years, numerous neuroimaging experiments have investigated aberrant brain activation during cognitive and emotional processing in patients with unipolar depression (UD). The results of those investigations, however, vary considerably; moreover, previous meta-analyses also yielded inconsistent findings. OBJECTIVE: To readdress aberrant brain activation in UD as evidenced by neuroimaging experiments on cognitive and/or emotional processing. DATA SOURCES: Neuroimaging experiments published from January 1, 1997, to October 1, 2015, were identified by a literature search of PubMed, Web of Science, and Google Scholar using different combinations of the terms fMRI (functional magnetic resonance imaging), PET (positron emission tomography), neural, major depression, depression, major depressive disorder, unipolar depression, dysthymia, emotion, emotional, affective, cognitive, task, memory, working memory, inhibition, control, n-back, and Stroop. STUDY SELECTION: Neuroimaging experiments (using fMRI or PET) reporting whole-brain results of group comparisons between adults with UD and healthy control individuals as coordinates in a standard anatomic reference space and using an emotional or/and cognitive challenging task were selected. DATA EXTRACTION AND SYNTHESIS: Coordinates reported to show significant activation differences between UD and healthy controls during emotional or cognitive processing were extracted. By using the revised activation likeli...