New Approach for Sustained Release Dosage Form Design: Aceclofenac

作者：Ahsan Habib, F. Mahmud, Tabinda Islam, Moynul Hasan, Sayed Koushik Ahamed, Moktasd Billah, Paroma Arefin · 发表于：NRCT Data Center · 年份：2015 · DOI：10.14456/mujps.2015.12 · 被引用次数：4 · 研究领域：Drug Solubulity and Delivery Systems、Pharmaceutical studies and practices、Advanced Drug Delivery Systems

In pharmaceutical dosage form preparation, eggshell powder has been explored for the new application as pharmaceutical excipient. So, our present study was undertaken to develop sustained release (SR) matrix tablets of aceclofenac using eggshell powder as newly investigated pharmaceutical excipient. Two different eggshell powders were used. These included ethanol treated and chloroform treated eggshell powders. The treated samples were prepared by surface modification using 1.0 % w/v stearic acid in solvent namely deionized water, 95 % ethanol and chloroform. Different formulations (F1-F6) were prepared by wet granulation method along with HPMC, treated eggshell powder as release retardant polymer and other ingredients. Dissolution studies of six aceclofenac formulations in pH 6.8 phosphate buffer were performed using USP Dissolution Apparatus II. The evaluation involves two stages-the physical properties studies of tablets and in vitro release kinetics assessment. The release kinetics was analyzed using Zero order and Higuchi’s equation. Significant differences were found among the drug release profile from different levels of using HPMC and treated eggshell. From Higuchi model plot it was found that chloroform treated eggshell powder containing formulation (F-5) shows most amendable sustain release over 24 hours than ethanol treated eggshell powder containing formulation (F-3). The in-vitro release studies revealed that F-5 can be taken as an ideal or optimized formulation ...