Radical (Phenylsulfonyl)difluoromethylation of Isocyanides with PhSO 2 CF 2 H under Transition-Metal-Free Conditions

作者：Pan Xiao, Jian Rong, Chuanfa Ni, Junkai Guo, Xinjin Li, Dingben Chen, Jinbo Hu · 发表于：Organic Letters · 年份：2016 · DOI：10.1021/acs.orglett.6b03013 · 被引用次数：74 · 研究领域：Fluorine in Organic Chemistry、Inorganic Fluorides and Related Compounds、Sulfur-Based Synthesis Techniques

An atom-economical method for radical (phenylsulfonyl)difluoromethylation of isocyanides with PhSO 2 CF 2 H under transition-metal-free conditions has been developed. A PhSO 2 CF 2 radical is generated through the oxidation of PhSO 2 CF 2 – after the deprotonation of PhSO 2 CF 2 H in one pot. The reaction exhibits excellent functional-group tolerance and the resulting products can be further modified with the removal of a PhSO 2 group to give other CF 2 -containing compounds.