Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity

作者：Yuan Cao, Tao Shen, Xiuqing Huang, Yajun Lin, Beidong Chen, Jing Pang, Guoping Li, Que Wang, Sylvia Zohrabian, Chao Duan, Yang Ruan, Yong Man, Shu Wang, Jian Li · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.13596 · 被引用次数：99 · 研究领域：Chemotherapy-induced cardiotoxicity and mitigation、Takotsubo Cardiomyopathy and Associated Phenomena、Electron Spin Resonance Studies

// Yuan Cao 1 , Tao Shen 1 , Xiuqing Huang 1 , Yajun Lin 1 , Beidong Chen 1 , Jing Pang 1 , Guoping Li 1 , Que Wang 1 , Sylvia Zohrabian 2 , Chao Duan 3 , Yang Ruan 4 , Yong Man 1 , Shu Wang 1 , Jian Li 1 1 Peking University Fifth School of Clinical Medicine, The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, 100730, China 2 Department of Cardiology, Boston Children’s Hospital, Enders 1250, Boston, MA, 02115, US 3 Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing 100037, China 4 Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China Correspondence to: Tao Shen, email: shentao4189@bjhmoh.cn Jian Li, email: lijian@bjhmoh.cn Keywords: astragalus polysaccharide, doxorubicin, cardiomyocyte, autophagy, AMPK/mTOR Received: August 20, 2016     Accepted: November 08, 2016     Published: November 25, 2016 ABSTRACT Doxorubicin (adriamycin), an anthracycline antibiotic, is commonly used to treat many types of solid and hematological malignancies. Unfortunately, clinical usage of doxorubicin is limited due to the associated acute and chronic cardiotoxicity. Previous studies demonstrated that Astragalus polysaccharide (APS), the extracts of Astragalus membranaceus , had strong anti-tumor activities and anti-inflammatory effects. However, whether AP...