Urinary bisphenol A is associated with insulin resistance and obesity in reproductive‐aged women

作者：So‐hyeon Hong, Yeon‐Ah Sung, Young Sun Hong, Eun‐Hee Ha, Kyungah Jeong, Hyewon Chung, Hyejin Lee · 发表于：Clinical Endocrinology · 年份：2016 · DOI：10.1111/cen.13270 · 被引用次数：58 · 研究领域：Effects and risks of endocrine disrupting chemicals、Toxic Organic Pollutants Impact、Health, Environment, Cognitive Aging

BACKGROUND/OBJECTIVES: The prevalence of obesity has markedly increased and is closely related to insulin resistance. Although lifestyle and genetic predisposition are significant factors influencing the pathophysiology within the body, endocrine-disrupting chemicals (EDCs) are also important triggers of metabolic disturbance. We investigated the relationship between exposure to EDCs and insulin resistance and obesity in healthy, reproductive-aged women. SUBJECTS/METHODS: This cross-sectional analysis included 296 healthy, reproductive-aged women between 30 and 49 years. Metabolically healthy was defined as an absence of the components of metabolic syndrome. Urinary levels of bisphenol A (BPA), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono-n-butyl phthalate (MnBP) were measured by high-performance liquid chromatography and tandem mass spectroscopy (LC-MS). Homoeostatic model analysis of insulin resistance (HOMA-IR) was utilized as an index of insulin resistance. RESULTS: Urinary BPA levels were positively correlated with BMI, waist circumference, fasting serum insulin and HOMA-IR. MEHHP, MEOHP and MnBP were not associated with any of the above parameters. In the multiple regression analysis, the BPA levels were significantly associated with BMI and waist circumference after adjusting for age, smoking and alcohol consumption status, triglycerides (TG), total cholesterol (TC) and high-density lipoprotein (HDL). Fasting ins...