PET/MRI of metabolic activity in osteoarthritis: A feasibility study

作者：Feliks Kogan, Audrey P. Fan, Emily J. McWalter, E.H. Oei, Andrew Quon, Garry E. Gold · 发表于：Journal of Magnetic Resonance Imaging · 年份：2016 · DOI：10.1002/jmri.25529 · 被引用次数：88 · 研究领域：Osteoarthritis Treatment and Mechanisms、Bone and Joint Diseases、Lower Extremity Biomechanics and Pathologies

Purpose To evaluate positron emission tomography / magnetic resonance imaging (PET/MRI) knee imaging to detect and characterize osseous metabolic abnormalities and correlate PET radiotracer uptake with osseous abnormalities and cartilage degeneration observed on MRI. Materials and Methods Both knees of 22 subjects with knee pain or injury were scanned at one timepoint, without gadolinium, on a hybrid 3.0T PET‐MRI system following injection of 18 F‐fluoride or 18 F‐fluorodeoxyglucose (FDG). A musculoskeletal radiologist identified volumes of interest (VOIs) around bone abnormalities on MR images and scored bone marrow lesions (BMLs) and osteophytes using a MOAKS scoring system. Cartilage appearance adjacent to bone abnormalities was graded with MRI‐modified Outerbridge classifications. On PET standardized uptake values (SUV) maps, VOIs with SUV greater than 5 times the SUV in normal‐appearing bone were identified as high‐uptake VOI (VOI High ). Differences in 18 F‐fluoride uptake between bone abnormalities, BML, and osteophyte grades and adjacent cartilage grades on MRI were identified using Mann–Whitney U ‐tests. Results SUV max in all subchondral bone lesions (BML, osteophytes, sclerosis) was significantly higher than that of normal‐appearing bone on MRI ( P < 0.001 for all). Of the 172 high‐uptake regions on 18 F‐fluoride PET, 63 (37%) corresponded to normal‐appearing subchondral bone on MRI. Furthermore, many small grade 1 osteophytes (40 of 82 [49%]), often described a...