Integrin α v β 3 -Targeted C-Dot Nanocomposites as Multifunctional Agents for Cell Targeting and Photoacoustic Imaging of Superficial Malignant Tumors

作者：Zhe Liu, Waner Chen, Yihong Li, Qien Xu · 发表于：Analytical Chemistry · 年份：2016 · DOI：10.1021/acs.analchem.6b03927 · 被引用次数：25 · 研究领域：Gold and Silver Nanoparticles Synthesis and Applications、Nanoplatforms for cancer theranostics、Extracellular vesicles in disease

With a cocktail formulation of soybean milk as a green carbon source and TTDDA as a capping agent, integrin α v β 3 -targeted C-dot nanocomposites (MB-CDs@NH-RGD) have been successfully fabricated via a facile microwaving protocol. Modification of the surface coating and RGD-conjugation endow their superior biocompatibility as well as highly specific targeting profile to α v β 3 -overexpressed cell lines of MDA-MB231 and B16 as representative superficial malignant tumors. Meanwhile, the significant photothermal effect has been generated on irradiation of these targeted C-dot nanocomposites by a pulsed laser, which proved their eligibility for potential thermal ablation therapy. In vivo photoacoustic imaging using these C-dot nanocomposites as novel imaging probes verified their excellent targeting sensitivity and contrast enhancement. This exciting evidence implies a promising strategy to utilize them for multifunctional nanotheranostic purposes in combination with precision diagnosis and photothermal treatment against superficial malignant tumors.