Circulating CD14 + HLA‐DR −/low myeloid‐derived suppressor cells predicted early recurrence of hepatocellular carcinoma after surgery

作者：Xinghui Gao, Lu Tian, Jiong Wu, Xiaolu Ma, Chunyan Zhang, Yan Zhou, Yun‐Fan Sun, Bo Hu, Shuang‐Jian Qiu, Jian Zhou, Jia Fan, Wei Guo, Xin‐Rong Yang · 发表于：Hepatology Research · 年份：2016 · DOI：10.1111/hepr.12831 · 被引用次数：71 · 研究领域：Immune cells in cancer、Inflammation biomarkers and pathways、Ferroptosis and cancer prognosis

AIM: Myeloid-derived suppressor cells (MDSCs) play an important role in tumor progression. The aim of the present study was to investigate the prognostic value of MDSCs for early recurrence of hepatocellular carcinoma (HCC) in patients undergoing curative resection. METHODS: Myeloid-derived suppressor cells were measured by flow cytometry. The correlation between MDSCs and tumor recurrence was analyzed using a cohort of 183 patients who underwent curative resection between February 2014 and July 2015. Prognostic significance was further assessed using Kaplan-Meier survival estimates and log-rank tests. RESULTS: MDSCs was significantly higher in HCC patients (3.7 ± 5.3%, n = 183) than in chronic hepatitis patients (1.4 ± 0.6%, n = 25) and healthy controls (1.1 ± 0.5%, n = 50). High frequency of MDSCs was significantly correlated with recurrence (time to recurrence) (P < 0.001) and overall survival (P = 0.034). Patients with HCC in the high MDSC group were prone to more vascular invasion (P = 0.018) and high systemic immune-inflammation index (SII) (P = 0.009) than those in the low MDSC group. Scatter-plot analyses revealed a significant positive correlation between the SII level and the frequency of MDSCs (r = 0.188, P = 0.011). Patients with HCC with a high MDSC frequency and high SII level had significantly shorter time to recurrence (P < 0.001) and overall survival (P = 0.028) than those with a low MDSC frequency and low SII. CONCLUSIONS: An increased frequency of MDSCs was...