β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer

作者：Jinxiao Liang, Hui Zhou, Yongpai Peng, Xiaofei Xie, Ruixin Li, Yunyun Liu, Qingsheng Xie, Zhongqiu Lin · 发表于：BioMed Research International · 年份：2016 · DOI：10.1155/2016/4923903 · 被引用次数：14 · 研究领域：Wnt/β-catenin signaling in development and cancer、Cancer-related gene regulation、Kruppel-like factors research

Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC). However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such as β -catenin and Wnt inhibitory factor 1 (WIF1). In this study, β-catenin and WIF1 expression were analyzed by immunohistochemistry for 196 patients with CC, 39 with cervical intraepithelial neoplasia (CIN), and 41 with normal cervical epithelium (NCE). Significant overexpression of β-catenin was detected in CC (67.9%) when compared to CIN (43.6%) or NCE (34.1%), p < 0 . 01 , while low WIF1 expression was detected in CC (24.0%) when compared to CIN (59.0%) or NCE (58.5%), p < 0 . 001 . Negative correlation was shown between β-catenin and WIF1 expression ( r = - 0 . 637 , p < 0 . 0 01 ). In addition, multivariate analysis revealed that both lymph node metastasis and β-catenin expression were the independent prognostic factors not only for disease-free survival (HR = 5.029, p < 0.001 ; HR = 2.588, p = 0 . 0 35 , resp.), but also for overall survival (HR = 5.058, p < 0.001 ; HR = 2.873, p = 0 . 0 31 , resp.). Our findings indicate that, besides lymph node metastasis, β -catenin expression may also be a poor prognostic factor for CC while WIF1 could be a potential drug target for treatment of advanced CC.