Development of Axially Chiral Cyclo‐Biaryldiol Ligands with Adjustable Dihedral Angles

作者：Pengxiang Zhang, Jipan Yu, Fei Peng, Xudong Wu, Jiyang Jie, Can Liu, Hua Tian, Haijun Yang, Hua Fu · 发表于：Chemistry - A European Journal · 年份：2016 · DOI：10.1002/chem.201603706 · 被引用次数：25 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Asymmetric Synthesis and Catalysis、Molecular spectroscopy and chirality

A new type of axially chiral cyclo-[1,1'-biphenyl]-2,2'-diol (CYCNOL) ligands with adjustable dihedral angles have been developed by varying the bridge chain length. Eight-, nine- and ten-membered cyclo-ligands were prepared and evaluated by using two representative examples: enantioselective additions of diethylzinc to aldehydes and organometallic reagents to enones. The results revealed that the fine regulation of dihedral angles through variation of the bridge chain length was effective in the asymmetric synthesis.