Type 1 Innate Lymphoid Cell Biology: Lessons Learnt from Natural Killer Cells

作者：Yuhao Jiao, Nicholas D. Huntington, Gabrielle T. Belz, Cyril Seillet · 发表于：Frontiers in Immunology · 年份：2016 · DOI：10.3389/fimmu.2016.00426 · 被引用次数：85 · 研究领域：IL-33, ST2, and ILC Pathways、Immune Cell Function and Interaction、Eosinophilic Esophagitis

Group 1 innate lymphoid cells (ILCs) comprise the natural killer (NK) cells and ILC1s that reside within peripheral tissues. Several different ILC1 subsets have recently been characterized; however, no unique markers have been identified that uniquely define these subsets. Whether ILC1s and NK cells are in fact distinct lineages, or alternately exhibit transitional molecular programs that allow them to adapt to different tissue niches remains an open question. NK cells are the prototypic member of the Group 1 ILCs and have been historically assigned the functions of what now appears to be a multi-subset family that are distributed throughout the body. This raises the question of whether each of these populations mediate distinct functions during infection and tumor immunosurveillance. Here, we review the diversity of the Group 1 ILC subsets in their transcriptional regulation, localization, mobility, and receptor expression, and highlight the challenges in unraveling the individual functions of these different populations of cells.