Rothia mucilaginosa Bacteremia and Subsequent Typhlitis in a Patient With Acute Myeloid Leukemia

作者：Emmanuel Bassily, Sean Verma, Sowmya Nanjappa, Olivia Bassily, John Greene · 发表于：Infectious Diseases in Clinical Practice · 年份：2016 · DOI：10.1097/ipc.0000000000000458 · 被引用次数：5 · 研究领域：Mycobacterium research and diagnosis、Diphtheria, Corynebacterium, and Tetanus、Infections and bacterial resistance

Abstract Rothia mucilaginosa is a gram-positive coccobacilli that is part of the normal flora of the human oropharynx and upper respiratory tract. Rothia spp. cause a wide range of serious infections, especially in immunocompromised hosts. We report a 54-year-old man with acute myelogenous leukemia, who recently had gingivitis and tooth extraction in preparation for bone marrow transplant evaluation. After receiving induction chemotherapy with cladribine, cytarabine, filgrastim, and mitoxantrone, he developed an upper gingival ulceration and subsequent Rothia mucilaginosa bacteremia on day 15 of hospitalization. He remained neutropenic on broad-spectrum antimicrobials and had intermittent breakthrough fevers. On day 17, he developed abdominal pain and was subsequently diagnosed with neutropenic enterocolitis. Despite broad-spectrum antibiotics, he died with sepsis and multiorgan failure.