Selesconol, a Fungal Polyketide That Induces Stem Cell Differentiation

作者：Ai Hua Zhang, Rui Tan, Rui Tan, Nan Jiang, Kaidiriye Yusupu, Xin Lei Wang, Xin Lei Wang, Ren Xiang Tan, Ren Xiang Tan · 发表于：Organic Letters · 年份：2016 · DOI：10.1021/acs.orglett.6b02688 · 被引用次数：23 · 研究领域：3D Printing in Biomedical Research、Cholinesterase and Neurodegenerative Diseases、Planarian Biology and Electrostimulation

Owing to the negligible or acceptable immunogenicity, small molecules capable of inducing the differentiation of undifferentiated stem cells into organ-specific cell types are particularly promising in developing replacement therapy, but such compounds with undescribed architectures are extremely rare. Selesconol (1) is discovered from the culture of Daldinia eschscholzii IFB-TL01 as a skeletally unprecedented inducer for the differentiation of rat bone marrow mesenchymal stem cells into neural cells, with its unique framework clarified to derive from the intermediate tautomerization of the dalesconol A biosynthetic pathway.