Copper-Mediated Oxidative Functionalization of C(sp 3 )–H Bonds with Isoquinolines: Two-Step Synthesis of 5-Oxaprotoberberinones

作者：Dingyi Wang, Rongxing Zhang, Rui-Hong Deng, Sen Lin, Shengmei Guo, Zhaohua Yan · 发表于：The Journal of Organic Chemistry · 年份：2016 · DOI：10.1021/acs.joc.6b02145 · 被引用次数：21 · 研究领域：Catalytic C–H Functionalization Methods、Alkaloids: synthesis and pharmacology、Chemical synthesis and alkaloids

)-H bonds with isoquinolines via a radical process without ligands was achieved. The present system exhibits a novel pathway for the preparation of N-alkyl (benzyl) isoquinolin-1(2H)-ones in moderate to high yields. In addition, this procedure provides a simple method to afford 5-oxaprotoberberinones and their derivatives in two steps.