Quantitative Liver Function Analysis: Volumetric T1 Mapping with Fast Multisection B1Inhomogeneity Correction in Hepatocyte-specific Contrast-enhanced Liver MR Imaging

作者：Jeong Hee Yoon, Jeong Min Lee, Eunju Kim, Tomoyuki Okuaki, Joon Koo Han · 发表于：Radiology · 年份：2016 · DOI：10.1148/radiol.2016152800 · 被引用次数：80 · 研究领域：Liver Disease Diagnosis and Treatment、Liver Disease and Transplantation、Hepatocellular Carcinoma Treatment and Prognosis

Purpose To determine whether B1 inhomogeneity–corrected volumetric T1 maps of gadoxetic acid–enhanced liver magnetic resonance (MR) imaging are able to demonstrate global liver function and functional heterogeneity in patients with cirrhosis and to investigate their relationship with the development of hepatic insufficiency and decompensation. Materials and Methods This institutional review board–approved retrospective study with waiver of informed consent included 234 consecutive patients who underwent gadoxetic acid–enhanced liver MR imaging, including B1 inhomogeneity–corrected volumetric T1 mapping. For all patients, T1 relaxation times of the liver and liver volumes were measured on T1 maps. Liver T1 and functional liver volume–to-weight ratio (liver volume divided by liver T1 and the patient’s weight) were compared between Child-Pugh class A and class B cirrhosis. Associations between serum markers, MR parameters, hepatic insufficiency, and decompensation were investigated by using Cox proportional hazards analysis. Results Patients with Child-Pugh class B disease showed significantly longer liver T1 (548.2 msec ± 257.7 vs 372.2 msec ± 77.5, P < .0001) and lower kurtosis of liver T1 (29.1 ± 39.6 vs 43.9 ± 64.9, P = .016) than patients with Child-Pugh class A disease. Prolonged liver T1 (≥462 msec) (hazard ratio [HR], 5.9; 95% confidence interval [CI]: 1.1, 62.8) and an albumin level of less than 3.5 g/dL (HR, 20.7; 95% CI: 3.9, 221.9) were independently associated with ...