New lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp. 318 #

作者：Jiguo Huang, Jiayi Xu, Zhen Wang, Dilfaraz Khan, Shah Iram Niaz, Yonghong Zhu, Yongcheng Lin, Jing Li, Lan Liu · 发表于：Natural Product Research · 年份：2016 · DOI：10.1080/14786419.2016.1239096 · 被引用次数：41 · 研究领域：Plant Pathogens and Fungal Diseases、Microbial Natural Products and Biosynthesis、Fungal Biology and Applications

Two new lasiodiplodins (1–2) together with three known analogues, were isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318#. Their structures were established by spectroscopic techniques (1D- and 2D-NMR, HR-ESI-MS, etc.), and electronic circular dichroism. Cytotoxic activities of compounds 1–5 were evaluated in vitro. Compound 4 was the most potent, with IC50 values of 5.29 μM against MMQ, 13.05 μM against GH3. Preliminary structural-activity analysis indicated that the functional group (resorcinol-3-OH) contributed greatly to the binding of Lasiodiplodins to the cytotoxic activities.