Relationships between <em>MGMT</em> promoter methylation and gastric cancer: a meta-analysis

作者：Dan Yu, Tao Cao, Ya‐di Han, Fusheng Huang · 发表于：OncoTargets and Therapy · 年份：2016 · DOI：10.2147/ott.s114052 · 被引用次数：8 · 研究领域：Epigenetics and DNA Methylation、Cancer Genomics and Diagnostics、RNA modifications and cancer

Abstract: A DNA repair enzyme, O6-methylguanine-DNA methyltransferase ( MGMT ), plays an important role in the development of gastric cancers. However, the role of MGMT promoter methylation in the occurrence of gastric cancer and its relationships with clinicopathologic characteristics has not been fully clarified. Thus, we performed a meta-analysis to evaluate the associations between MGMT promoter methylation and gastric cancer. Electronic databases, including PubMed and Web of Science, were used to systematically search related clinical studies published in English until April 1, 2016. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to evaluate the associations between MGMT promoter methylation and gastric cancer risk or clinicopathologic characteristics. A total of 16 studies including 1,935 patients and 1,948 control persons were included in the analysis. Our study suggested that MGMT promoter methylation frequency was associated with gastric cancer (OR=3.46, 95% CI: 2.13–5.61, P <0.001). Moreover, the frequency of MGMT promoter methylation in the no lymph node metastasis group was lower than that in lymph node metastasis group, with marginal significance (OR=0.65, 95% CI: 0.42–1.01, P =0.05). Additionally, the methylation rate of the MGMT promoter was much lower in patients without distant metastases than in those with metastases (OR=0.27, 95% CI: 0.18–0.40, P <0.001). No significant association of MGMT promoter methylation with Lauren classific...