Application of Zebrafish Model to Environmental Toxicology

作者：Yuta Komoike, Masato Matsuoka · 发表于：Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · 年份：2016 · DOI：10.1265/jjh.71.227 · 被引用次数：6 · 研究领域：Environmental Toxicology and Ecotoxicology、Zebrafish Biomedical Research Applications、Toxic Organic Pollutants Impact

Recently, a tropical freshwater fish, the zebrafish, has been generally used as a useful model organism in various fields of life science worldwide. The zebrafish model has also been applied to environmental toxicology; however, in Japan, it has not yet become widely used. In this review, we will introduce the biological and historical backgrounds of zebrafish as an animal model and their breeding. We then present the current status of toxicological experiments using zebrafish that were treated with some important environmental contaminants, including cadmium, organic mercury, 2,3,7,8-tetrachlorodibenzo-p-dioxin, and tributyltin. Finally, the future possible application of genetically modified zebrafish to the study of environmental toxicology is discussed.