Photodynamic therapy of tumors with pyropheophorbide-<em>a</em>-loaded polyethylene glycol–poly(lactic-<em>co</em>-glycolic acid) nanoparticles

作者：Zhangyong Hong, Hui Liu, Mei Zhao, Jin Wang, Mingpei Pang, Zhenhua Wu, Liqing Zhao, Zhinan Yin · 发表于：International Journal of Nanomedicine · 年份：2016 · DOI：10.2147/ijn.s112541 · 被引用次数：16 · 研究领域：Photodynamic Therapy Research Studies、Nanoplatforms for cancer theranostics、Cancer Research and Treatments

Abstract: Photodynamic therapy (PDT) has many advantages in treating cancers, but the lack of ideal photosensitizers continues to be a major limitation restricting the clinical utility of PDT. This study aimed to overcome this obstacle by generating pyropheophorbide- a -loaded polyethylene glycol–poly(lactic- co -glycolic acid) nanoparticles (NPs) for efficient tumor-targeted PDT. The fabricated NPs were efficiently internalized in the mitochondrion by cancer cells, and they efficiently killed cancer cells in a dose-dependent manner when activated with light. Systemically delivered NPs were highly enriched in tumor sites, and completely ablated the tumors in a xenograft KB tumor mouse model when illuminated with 680 nm light (156 mW/cm 2 , 10 minutes). The results suggested that this tumor-specific NP-delivery system for pyropheophorbide- a has the potential to be used in tumor-targeted PDT. Keywords: photodynamic therapy, photosensitizer, pyropheophorbide- a , nanoparticle