Protective Effects of Hydrogen against Low‐Dose Long‐Term Radiation‐Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice

作者：Jiaming Guo, Deyun Zhao, Xiao Lei, Hainan Zhao, Yanyong Yang, Pei Zhang, Pengfei Liu, Yang Xu, Meizhou Zhu, Hu Liu, Yuanyuan Chen, Yunhai Chuai, Bailong Li, Fu Gao, Jianming Cai · 发表于：Oxidative Medicine and Cellular Longevity · 年份：2016 · DOI：10.1155/2016/1947819 · 被引用次数：14 · 研究领域：Hydrogen's biological and therapeutic effects、Anesthesia and Neurotoxicity Research、Biochemical effects in animals

Molecular hydrogen (H 2 ) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H 2 on the alterations induced by low‐dose long‐term radiation (LDLTR). All the mice in hydrogen‐treated or radiation‐only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole‐body gamma radiation, respectively. After the last time of radiation exposure, all the mice were employed for the determination of the body mass (BM) observation, forced swim test (FST), the open field test (OFT), the chromosome aberration (CA), the peripheral blood cells parameters analysis, the sperm abnormality (SA), the lymphocyte transformation test (LTT), and the histopathological studies. And significant differences between the treatment group and the radiation‐only groups were observed, showing that H 2 could diminish the detriment induced by LDLTR and suggesting the protective efficacy of H 2 in multiple systems in mice against LDLTR.