FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma

作者：Lisha Qi, Wangzhao Song, Lingmei Li, Lu Cao, Yue Yu, Chun-Min Song, Yalei Wang, Fei Zhang, Yang Li, Bin Zhang, Wenfeng Cao · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.12187 · 被引用次数：53 · 研究领域：Fibroblast Growth Factor Research、Wnt/β-catenin signaling in development and cancer、Neonatal Respiratory Health Research

// Lisha Qi 1, 5, 6 , Wangzhao Song 1, 4, 5, 6 , Lingmei Li 1, 5, 6 , Lu Cao 1, 4, 5, 6 , Yue Yu 2, 5, 6 , Chunmin Song 8 , Yalei Wang 1, 5, 6 , Fei Zhang 5, 6, 7 , Yang Li 3, 4, 5, 6 , Bin Zhang 2, 5, 6 , Wenfeng Cao 1, 5, 6 1 Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 2 Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 3 Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 4 Tianjin Medical University, Tianjin 300070, China 5 The Key Laboratory of Tianjin Cancer Prevention and Treatment, Tianjin 300060, China 6 National Clinical Research Center for Cancer, Tianjin 300060, China 7 Research Center of Basic Medical Sciences, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 8 Department of Family Planning, Maternity & Child Care Center of Luoyang, Luoyang 471000, China Correspondence to: Bin Zhang, email: eeflying@163.com Wenfeng Cao, email: caowenfeng@tjmuch.com Keywords: FGF4, epithelial-mesenchymal transition, store-operated calcium entry, Orai1, FGF7 Received: February 04, 2016      Accepted: August 23, 2016      Published: September 22, 2016 ABSTRACT Several fibroblast growth factor (FGF) isoforms act to stimulate epithelial-mesenchymal transition (EMT) during cancer progression. FGF4 and FGF7 are two ligands of...