Commissural axon navigation: Control of midline crossing in the vertebrate spinal cord by the semaphorin 3B signaling

作者：Aurora Pignata, Hugo Ducuing, Valérie Castellani · 发表于：Cell Adhesion & Migration · 年份：2016 · DOI：10.1080/19336918.2016.1212804 · 被引用次数：23 · 研究领域：Axon Guidance and Neuronal Signaling、Zebrafish Biomedical Research Applications、Nerve injury and regeneration

The mechanisms governing the navigation of commissural axons during embryonic development have been extensively investigated in the past years, often using the drosophila ventral nerve cord and the spinal cord as model systems. Similarities but also specificities in the general strategies, the molecular signals as well as in the regulatory pathways controlling the response of commissural axons to the guidance cues have been found between species. Whether the semaphorin signaling contributes to midline crossing in the fly nervous system remains unknown, while in contrast, it does play a prominent contribution in vertebrates. In this review we discuss the functions of the semaphorins during commissural axon guidance in the developing spinal cord, focusing on the family member semaphorin 3B (Sema3B) in the context of midline crossing in the spinal cord.