Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013

作者：Hmwe Hmwe Kyu, Victoria F Bachman, Lily Alexander, John Everett Mumford, Ashkan Afshin, Kara Estep, Lennert Veerman, Kristen Delwiche, Marissa Iannarone, Madeline L Moyer, Kelly Cercy, Theo Vos, Christopher J L Murray, Mohammad H. Forouzanfar · 发表于：BMJ · 年份：2016 · DOI：10.1136/bmj.i3857 · 被引用次数：1299 · 研究领域：Physical Activity and Health、Cancer Risks and Factors、Cardiovascular Health and Risk Factors

OBJECTIVE: To quantify the dose-response associations between total physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events. DESIGN: Systematic review and Bayesian dose-response meta-analysis. DATA SOURCES: PubMed and Embase from 1980 to 27 February 2016, and references from relevant systematic reviews. Data from the Study on Global AGEing and Adult Health conducted in China, Ghana, India, Mexico, Russia, and South Africa from 2007 to 2010 and the US National Health and Nutrition Examination Surveys from 1999 to 2011 were used to map domain specific physical activity (reported in included studies) to total activity. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Prospective cohort studies examining the associations between physical activity (any domain) and at least one of the five diseases studied. RESULTS: 174 articles were identified: 35 for breast cancer, 19 for colon cancer, 55 for diabetes, 43 for ischemic heart disease, and 26 for ischemic stroke (some articles included multiple outcomes). Although higher levels of total physical activity were significantly associated with lower risk for all outcomes, major gains occurred at lower levels of activity (up to 3000-4000 metabolic equivalent (MET) minutes/week). For example, individuals with a total activity level of 600 MET minutes/week (the minimum recommended level) had a 2% lower risk of diabetes compared with those reporting no physical activity. An increase ...