Clinical Efficacy of Acupuncture Treatment in Combination With RehaCom Cognitive Training for Improving Cognitive Function in Stroke: A 2 × 2 Factorial Design Randomized Controlled Trial

作者：Cai Jiang, Shanli Yang, Jing Tao, Jia Huang, Yinyan Li, Haicheng Ye, Shanjia Chen, Wenjun Hong, Lidian Chen · 发表于：Journal of the American Medical Directors Association · 年份：2016 · DOI：10.1016/j.jamda.2016.07.021 · 被引用次数：68 · 研究领域：Acupuncture Treatment Research Studies、Stroke Rehabilitation and Recovery、Botulinum Toxin and Related Neurological Disorders

Objective The aim of this study was to identify the clinical efficacy of acupuncture in combination with RehaCom cognitive training in poststroke patients with cognitive dysfunction. Methods/Design This study was a 2 × 2 factorial design randomized controlled trial comparing acupuncture, computer-assisted cognitive rehabilitation, and the usual treatment by per-protocol analysis. The trial was completed by 204 stroke patients, including 49 patients in a control group, 52 patients in an acupuncture treatment group, 51 patients in a RehaCom training group, and 52 patients in an acupuncture combined with RehaCom group. All of the patients accepted basic treatment and health education. The interventions continued for 12 weeks (30 minutes per day, 5 days per week). The relative cognitive and functional outcomes were measured at baseline and 12 weeks (at the end of intervention) using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Functional Independence Measure (FIM) scales. Results After 12 weeks of treatment, the functional statuses of the patients in each of the 4 groups showed varying degrees of improvement. Multiple comparisons of the changes in the MMSE, MoCA, and FIM scores indicated that acupuncture combined with RehaCom cognitive training (ACR) had enhanced therapeutic effects on the functional statuses of the stroke patients ( P < .05). In addition, ACR had similar therapeutic effects on the functional statuses of the stroke patients ...