Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease

作者：Jianxin Wan, Yanhong Wang, Gaorong Cai, Jianbo Liang, Caifeng Yue, Fen Wang, Junli Song, Jianfeng Wang, Min Liu, Jinmei Luo, Laisheng Li · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.11682 · 被引用次数：56 · 研究领域：Chronic Kidney Disease and Diabetes、Renal Diseases and Glomerulopathies、Renin-Angiotensin System Studies

// Jianxin Wan 1,* , Yanhong Wang 2,* , Gaorong Cai 1,* , Jianbo Liang 1 , Caifeng Yue 1 , Fen Wang 3 , Junli Song 4 , Jianfeng Wang 5 , Min Liu 1 , Jinmei Luo 2 and Laisheng Li 1 1 Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China 2 Department of Internal Medicine, Medical Intensive Care Unit and Division of Respiratory Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China 3 Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China 4 Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China 5 Institute of Laboratory Medicine, Guangdong Medical College, Dongguan, People’s Republic of China * These authors have contributed equally to this work Correspondence to: Laisheng Li, email: // Jinmei Luo, email: // Keywords : HE4; diagnostic; renal fibrosis; kidney disease; biomarkers; Pathology Section Received : June 16, 2016 Accepted : August 26, 2016 Published : August 29, 2016 Abstract Background: Human epididymis protein 4 (HE4), has recently been reported as a mediator of renal fibrosis. However, serum HE4 levels appear in a large number of patient samples with chronic kidney disease (CKD), and the relationship of these levels to disease severity and renal fibrosis is unknown. Methods: In 427 patie...